Cloning and functional expression of a mouse liver organic cation transporter
نویسندگان
چکیده
منابع مشابه
Cloning and functional expression of a human liver organic cation transporter.
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and xenobiotics. In contrast to our understanding of the mechanisms of organic cation transport in rat liver, little is known about the mechanisms of organic cation transport in the human liver. We report the cloning, sequencing, and functional characterization of the first human p...
متن کاملFunctional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.
Carnitine/organic cation transporter (OCTN1/SLC22A4) accepts various therapeutic agents as substrates in vitro and is expressed ubiquitously, although its function in most organs has not yet been examined. The purpose of the present study was to evaluate functional expression of OCTN1 in small intestine and liver, using octn1 gene knockout [octn1(-/-)] mice. After oral administration of [(3)H]e...
متن کاملMolecular cloning of rabbit organic cation transporter rbOCT2 and functional comparisons with rbOCT1.
Multiple organic cation transporters (OCTs) are present in rabbit kidney and may play different functional roles. We cloned rabbit OCT2 (rbOCT2) and compared its function with that of rabbit OCT1 (rbOCT1). In transiently transfected COS-7 cells, rbOCT1 and rbOCT2 mediated uptake of [3H]tetraethylammonium (TEA) with K(t) values of 188 and 125 microM, respectively. n-Tetraalkylammonium compounds ...
متن کاملMolecular Cloning of the Rabbit Organic Cation Transporter, rbOCT2, and Functional Comparisons with rbOCT1
Cloning of the Rabbit Organic Cation Transporter, rbOCT2, and Functional Comparisons with rbOCT1. Am J. Physiol. Renal Physiol. Multiple organic cation (OC) transporters are present in rabbit kidney and may play different functional roles. We cloned rbOCT2 and compared its function with that of rbOCT1. In transiently transfected COS-7 cells, rbOCT1 and rbOCT2 mediated uptake of [ 3 H]tetraethyl...
متن کاملFunctional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
We have demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a transporter for organic cations as well as carnitine. OCTN2 transports organic cations without involving Na(+), but it transports carnitine only in the presence of Na(+). The ability to transport organic cations and carnitine is demonstrable with human, rat, and mouse OCTN2s. Na(+) does not influence t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hepatology
سال: 1999
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510290530